Publications & Presentations

BVD Authored

Cancer Research Communications, May 2024

A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma

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Nature Communications, March 2024

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer

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AACR ANNUAL MEETING, 2023

Combining ulixertinib (ERK1/2 inhibitor) with EGFR and BRAF inhibition yields significant efficacy in preclinical BRAFV600E mutant colorectal cancer models

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AACR Annual Meeting, 2023

The combination of ulixertinib (ERK1/2 inhibitor) and KRASG12C inhibition demonstrates significant efficacy in preclinical models

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Neuro-Oncology, March 2023 (print); July 2022 (online)

The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models

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Melanoma Research, August 2022 (print); May 2022 (online)

Case report: response to the ERK1/2 inhibitor ulixertinib in BRAF D594G cutaneous melanoma

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AACR Annual Meeting, April 2022

ERK1/2 inhibitor ulixertinib demonstrates activity in atypical (non-V600) BRAF mutant models

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AACR ANNUAL MEETING, APRIL 2022

Significant efficacy demonstrated with the combination of ulixertinib (ERK1/2 inhibitor) and CDK4/6 inhibitors in MAPK altered models

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AACR ANNUAL MEETING, APRIL 2022

The characterization of in vitro models demonstrating a significant delay of acquired resistance to ulixertinib (ERK1/2)

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AACR ANNUAL MEETING, APRIL 2022

Identification of combination partners to combat acquired resistance to ulixertinib (ERK1/2 inhibitor) using transcriptomics

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Radiation Research, March 2022 (print); December 2021 (online)

Paired 18F-Fluorodeoxyglucose (18F-FDG), and 64Cu-Copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) (64Cu-ATSM) PET scans in dogs with spontaneous tumors and evaluation for hypoxia-directed therapy

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Nature / Biopharma Dealmakers, September 2021

Translational medicine: doing things differently

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Investigational New Drugs, June 2021 (print); January 2021 (online)

Characterization and management of ERK inhibitor associated dermatologic adverse events: analysis from a nonrandomized trial of ulixertinib for advanced cancers

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Clinical Cancer Research, January 2021 (print); October 2020 (online)

Intratumoral injection of Clostridium novyi-NT spores in patients with treatment-refractory advanced solid tumors

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Journal for ImmunoTherapy for Cancer, August 2018

White paper on microbial anti-cancer therapy and prevention

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The Journal of Clinical Investigation, June 2018 (online); July 2018 (print)

Tumor stroma–targeted antibody-drug conjugate triggers localized anticancer drug release

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Cancer Discovery, September 2018 (print); June 2018 (online)

Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

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BMC Veterinary Research, April 2018

Identification of immunologic and clinical characteristics that predict inflammatory response to C. novyi-NT bacteriolytic immunotherapy

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Veterinary Research, April 2018

Immune response to Clostridium novyi-NT immunotherapy

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Veterinary Research, April 2018

Translational and Clinical Development of Clostridium novyi-NT

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Cancer Chemotherapy and Pharmacology, June 2018 (print), March 2018 (online)

Effect of ulixertinib, a novel ERK1/2 inhibitor, on the QT/QTc interval in patients with advanced solid tumor malignancies

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Cancer Discovery, February 2018 (print); December 2017 (online)

First-in-class ERK1/2 inhibitor ulixertinib (BVD-523) in patients with MAPK mutant advanced solid tumors: results of a Phase I dose-escalation and expansion study

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Joint Meeting of the 9th World Congress of Melanoma and 14th International Congress of the Society for Melanoma Research, October 18 – 21, 2017

Activity of the ERK1/2 inhibitor ulixertinib in patients with BRAF and NRAS mutant melanoma

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Molecular Cancer Therapeutics, November 2017 (print); September 2017 (online)

Targeting the MAPK signaling pathway in cancer: promising preclinical activity with the novel selective ERK1/2 inhibitor BVD-523 (ulixertinib)

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National Cancer Institute (NCI) Conference on Microbial-Based Cancer Therapy, July 11-12, 2017

Clostridium novyi-NT: Transitional and Clinical Development

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American Society of Clinical Oncology (ASCO), June 2017

A first-in-class Phase 1 dose-escalation study of the novel oral ERK1/2 kinase inhibitor BVD-523 (ulixertinib) in patients with advanced solid tumors

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Cancer Cell, April 2017

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

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American Association for Cancer Research (AACR), April 2017

Activity of ERK1/2 inhibitor ulixertinib (BVD-523) in patients with BRAF and NRAS mutant melanoma

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EORTC-NCI-AACR Symposium, November 29 – December 6, 2016

Phase 1 clinical study of intratumoral injection of Clostridium novyi-NT spores in patients with advanced cancer

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Nuclear Medicine and Biology, May 2016 (print); February 2016 (online)

Human dosimetry and infection imaging in patients with suspected prosthetic joint infection

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American Society of Clinical Oncology (ASCO), June 2015

Dose escalation stage of a first-in-class Phase 1 study of the novel oral ERK1/2 kinase inhibitor BVD-523 (ulixertinib) in patients with advanced solid tumors

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American Association for Cancer Research (AACR), April 2015

The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance

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13th International Congress on Targeted Anticancer, March 2015

Phase 1 clinical study of intratumoral injection of Clostridium novyi-NT spores in patients with advanced cancer

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Symposium on Clinical Interventional Oncology (CIO), January 2015

Phase 1 trial of image-guided oncolysis by Clostridium novyi-NT spore inoculation: early technical insights

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PLoS One, Dec 2014

MRI-monitored intra-tumoral injection of iron-oxide labeled Clostridium novyi-NT anaerobes in pancreatic carcinoma mouse model

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Science Translational Medicine, August 2014

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

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World Journal of Microbiology and Biotechnology, August 2014

Evaluation of 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) as an ex vivo bacterial detection agent

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PLoS One, Aug 2014

Systematic repurposing screening in xenograft models identifies approved drugs with novel anti-cancer activity

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Current Therapeutic Research, December 2013

Possible therapeutic effect of trilostane in rodent models of inflammation and nociception

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Pharmacology, November 2013

Novel anti-inflammatory effects of doxazosin in rodent models of inflammation

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BMC Nephrology, October 2013

TNF-α blockade is ineffective in animal models of established polycystic kidney disease

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Current Therapeutic Research, September 2012

Differential effects of cyclosporin and etanercept treatment on various pathologic parameters in a murine model of irradiation-induced mucositis

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Current Therapeutic Research, December 2011

In vivo effects of immunomodulators in a murine model of Fluorouracil-induced mucositis

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Pharmacology, November 2011

Novel anti-inflammatory effects of repaglinide in rodent models of inflammation

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Diabetes, Obesity and Metabolism, November 2011

Effect of the antipsychotic agent amisulpride on glucose lowering and insulin secretion

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Pharmacology, August 2011

Anti-inflammatory and immunomodulatory effects of bortezomib in various in vivo models

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Supporting Literature

New Scientist, June 2023

Bugging cancer

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Journal for ImmunoTherapy of Cancer, September 2022

TEM8 Tri-specific Killer Engager binds both tumor and tumor stroma to specifically engage natural killer cell anti-tumor activity

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Biochemical Journal, April 2023

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

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Nature Communications, 2022

Cancer cell survival depends on collagen uptake into tumor-associated stroma

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Cancers, 2022

ERK Inhibitor Ulixertinib Inhibits High-Risk Neuroblastoma Growth In Vitro and In Vivo

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Nature Communications, 2021

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

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Cancer Management and Research, 2021

Clinical Value of Detecting Tumor Endothelial Marker 8 (ANTXR1) as a Biomarker in the Diagnosis and Prognosis of Colorectal Cancer

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The Journal of Clinical Investigation, July 2018

Deadly DAaRTS destroy cancer cells via a tumor microenvironment–mediated trigger

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Cancer Research, 2018

TEM8/ANTXR1-specific CAR T cells as a targeted therapy for triple-negative breast cancer

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